What Is The Fact Site?

What Is The Fact Site?

What Is The Fact Site?

The Fact Site is the #1 source for the most interesting and random facts. Every week we provide fun facts about animals, celebs, food, health, space & more! The Fact Site requires you to enable Javascript to browse our website. Home. 1000 Facts List.

What is factslides?

Factslides is dedicated to provide well-sourced and verified information that will help young people access the information and critical thinking skills they need to make our world a better place. Launched in July, 2013, it has shown its facts over 1000 million times, and was selected among the Top 100 websites…

How many passengers do you transport each year?

In the average year we transport around 40,000 passengers on journeys covering 400,000 miles. We have several services: These services are open to all: young, old, able-bodied or infirm.

Who can use the services of a public transport?

These services are open to all: young, old, able-bodied or infirm. The majority of journeys undertaken are for transporting passengers to medical services and day centres on behalf of the local authorities, but many others are for shopping, family visits and similar.

What is the fact transport scheme?

FACT operates as a charity serving Fenland and beyond, to people who have difficulties using conventional modes of transport. They aim to provide accessible, affordable and safe transport services. You must be a member of FACT to use this service. FACT has several services in the transportation scheme.

What is BACT Community Transport doing to help tackle loneliness?

Bact community transport is working in partnership with East Suffolk Council to help tackle loneliness and isolation during 2021/22. What’s our aim? To reach out to as many people as possible who are lonely and isolated to help ease their way back into everyday life as we emerge from the pandemic.

What is the problem with cancer?

The problem. Cancer is a leading cause of death worldwide, accounting for an estimated 9.6 million deaths in 2018. The most common cancers are: … Cancer arises from the transformation of normal cells into tumour cells in a multistage process that generally progresses from a pre-cancerous lesion to a malignant tumour. These changes are the …

What are 5 interesting facts about cancer?

47 Interesting Facts About Cancer 1 The word cancer comes from the Latin for ‘crab’. 2 Even lack of physical exercise can be a cause of cancer. 3 Cancers can be hereditary. 4 Do not be amazed to learn that only tobacco has killed at least 50 million people in the last ten years. 5 Cancer is not a disease in particular. More items…

What is cancers?

It is a condition where growth of abnormal cells in the body goes out of control. It is an uncontrolled division of the cells that are harmful to the body. 6. There are more than 200 types and sub-types of cancers that can affect an individual.

What is the function of the fact complex in hepatocellular carcinoma?

Objective: Facilitates Chromatin Transcription (FACT) complex is a histone chaperone participating in DNA repair-related and transcription-related chromatin dynamics. In this study, we investigated its oncogenic functions, underlying mechanisms and therapeutic implications in human hepatocellular carcinoma (HCC).

Why is chromatin important?

Chromatin organization is crucial for genome replication, transcriptional silencing, and DNA repair and recombination. The replication machinery is relevant for the maintenance of chromatin states, influencing DNA replication origin specification and accessibility.

Are histones enzymes?

Histone-modifying enzymes are enzymes involved in the modification of histone substrates after protein translation and affect cellular processes including gene expression. To safely store the eukaryotic genome, DNA is wrapped around four core histone proteins (H3, H4, H2A, H2B), which then join to form nucleosomes.

What does the fact Complex do?

It promotes histone removal, deposition and replacement on chromatin. Due to its role in chromatin dynamics, it has a role in many cellular processes related to chromatin: DNA replication, DNA damage and repair, transcription initiation and elongation.

How do histone chaperones work?

Histone chaperones safeguard the chromatin template and shield histones from promiscuous interactions to ensure their proper storage, transport, post-translational modification, nucleosome assembly and turnover.

What does fact stand for?

"Transcription Promotes the Interaction of the FAcilitates Chromatin Transactions (FACT) Complex with Nucleosomes in Saccharomyces cerevisiae". Genetics. 210 (3): 869–881. doi: 10.1534/genetics.118.301349.

What does fact complex stand for?

"Transcription Promotes the Interaction of the FAcilitates Chromatin Transactions (FACT) Complex with Nucleosomes in Saccharomyces cerevisiae". Genetics. 210 (3): 869–881. doi: 10.1534/genetics.118.301349. ISSN 0016-6731. PMC 6218215. PMID 30237209.

What does FACT stand for in biology?

A fact is an indisputable observation of a natural or social phenomenon. We can see it directly and show it to others. ​A hypothesis is an idea that we can test with further observations.

What is a histone chaperone?

Histone chaperones are now broadly defined as a group of proteins that bind histones and regulate nucleosome assembly1. In general, histone chaperones can be classified either as H3–H4 or H2A–H2B chaperones based on their preferential binding to H3–H4 or H2A–H2B, respectively.

What is the function of the fact complex?

Functioni. Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes…

What is the function of the fact complex in DNA replication?

The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure.